Posted DateDec. 8, 2014
Brief Description: Common Polyomaviruses can be severe and debilitating in immunocompromised patients with advanced age, HIV or an organ transplant are particularly susceptible. No effective vaccines or targeted therapies currently exist.The technology is a group of small molecule inhibitors that h...
small molecule inhibitors
block intracellular transport
technology includes methods
Posted DateNov. 13, 2015
Brief Description:Acyldepsipeptide (ADEP) antibiotics hold promise as antibacterial drugs in this time of drug resistance and the urgent need for more therapeutic options. ADEPs are molecules that act by binding to and activating the activity of ClpP peptidase – no antibacterial agents on the market...
act
bacteria
bacillus
tuberculosis
fragments
efflux
adeps
antibacterial
pumps
adep
Posted DateOct. 7, 2011
Current metabolomics analyses require the simultaneous identification and/or characterization of hundreds to thousands of metabolites in complex samples as indicators of disease. Isolation and detection techniques are required, and a common strategy is to chemically derivatize metabolites to impart ...
impart physiochemical properties
easily prepared substrates
existing analytic instrumentation
chemically derivatize metabolites
complex samples makes
Posted DateAug. 19, 2015
Brief Description:Infectious diseases are the second leading cause of death – globally. Antibiotic drug resistance is a major clinical and societal problem, with many long-standing antibiotics no longer affective against several emergent pathogenic microbial strains. The capability of bacteria to ro...
routinely develop resistance
casein lytic protease
antibiotic drug resistance
antibacterial agent necessitates
exhibit potent activity
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