A novel therapeutic for B Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL).
This strategy promotes and protects the adaptive immune system, rather than abrogating its protective effects. Importantly, this approach will spare mature B cells that mediate the adaptive arm of the immune response. This is a particularly important feature of this therapeutic, since patients are highly susceptible to secondary infections during the steroid and chemotherapy phases of treatment.
B Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) is a common neoplasm in children and is an aggressive disease in adolescents and young adults. Overall survival for BCP-ALL has gradually improved from 10% in the 1960s to approximately 90% presently. Select subsets of patients, however, appear to have not benefitted from risk-adapted, intensified therapies. Because outcomes for high-risk leukemias appear to have plateaued with conventional therapy, the need for less toxic therapies has become greater. A present need remains for novel therapeutic approaches to help patients with BCP-ALL.
Researchers at the University of New Mexico and Sea Lane Biotechnologies have developed a novel therapeutic for B Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL). More specifically, this strategy promotes and protects the adaptive immune system, rather than abrogating its protective effects. Importantly, this approach will spare mature B cells that mediate the adaptive arm of the immune response. This is a particularly important feature of this therapeutic, since patients are highly susceptible to secondary infections during the steroid and chemotherapy phases of treatment.
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approximately 90% presently
technology description researchers
sea lane biotechnologies
anti-cd22 targeted therapy
adaptive immune system
