Technologies

time icon July 7, 2015

Therapeutic Antibodies and their Derivatives to Target the pre-BCR in BCP-ALL

Technology description

A novel therapeutic for B Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL).

This strategy promotes and protects the adaptive immune system, rather than abrogating its protective effects. Importantly, this approach will spare mature B cells that mediate the adaptive arm of the immune response. This is a particularly important feature of this therapeutic, since patients are highly susceptible to secondary infections during the steroid and chemotherapy phases of treatment.

Background

B Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) is a common neoplasm in children and is an aggressive disease in adolescents and young adults. Overall survival for BCP-ALL has gradually improved from 10% in the 1960s to approximately 90% presently. Select subsets of patients, however, appear to have not benefitted from risk-adapted, intensified therapies. Because outcomes for high-risk leukemias appear to have plateaued with conventional therapy, the need for less toxic therapies has become greater. A present need remains for novel therapeutic approaches to help patients with BCP-ALL.

Technology Description

Researchers at the University of New Mexico and Sea Lane Biotechnologies have developed a novel therapeutic for B Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL). More specifically, this strategy promotes and protects the adaptive immune system, rather than abrogating its protective effects. Importantly, this approach will spare mature B cells that mediate the adaptive arm of the immune response. This is a particularly important feature of this therapeutic, since patients are highly susceptible to secondary infections during the steroid and chemotherapy phases of treatment.

Publications

Dynamic pre-BCR homodimers fine-tune autonomous survival signals in B cell precursor acute lymphoblastic leukemia

Macrophage and NK-mediated killing of precursor-B acute lymphoblastic leukemia cells targeted with a-fucosylated anti-CD19 humanized antibodies

Characterization of the anti-CD22 targeted therapy, moxetumomab pasudotox, for B-cell precursor acute lymphoblastic leukemia

About STC.UNM

As the technology-transfer and economic-development organization for the University of New Mexico, STC.UNM protects and commercializes technologies developed at the University of New Mexico (UNM) by filing patents and copyrights and transferring the technologies to the marketplace. We connect the business communication (companies, entrepreneurs and investors) to these UNM technologies for licensing opportunities and the creation of startup companies. Visit www.stc.unm.edu.

Application area

  • Therapeutic for B Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL)
  • Targets minimal residual disease (MRD), while protecting mature B cells and therefore favoring a functional immune response to control opportunistic infections that are significant mortality risks in BCP-ALL patients
  • Development of both peptidomimetic inhibitors and antibody-based approaches as targeted therapies
  • Possible to recruit healthy immune function in later stages of therapy

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More information

Categories
  • Pathology
  • Diagnosis and treatment
  • Hematology
Keywords:

approximately 90% presently

technology description researchers

sea lane biotechnologies

anti-cd22 targeted therapy

adaptive immune system

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