Aug. 15, 2017
Cardiovascular disease (CVD) is the leading cause of mortality around the world. In the United States alone, heart failure currently affects over 5 million people costing the nation an estimated $32 billion annually. A major limitation in cardiovascular drug development is that current CVD models lack relevance to native human tissue. The “Heart-on-a-chip” device overcomes these limitations, but the synthetic elastomer polydimethylsiloxane (PDMS) it uses for culturing cardiac cells is not suitable for long-term studies. The $120 billion market for CVD drugs will benefit from a device that provides conducive culture conditions to heart cells in a physiological microenvironment.
USC scientists have developed a gelatin hydrogel membrane to serve as the basement layer for culturing cardiac myocytes in a “Heart-on-a-chip” device using PDMS frames and a biodegradable mesh for added mechanical support. They also created a semi-permeable barrier that supports endothelial cells and mimics native vasculature. This device provides a physiological microenvironment conducive to long-term culturing of heart cells.
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cardiovascular drug development
native human tissue
synthetic elastomer polydimethylsiloxane
$120 billion market
conducive culture conditions
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