Technologies

Background

The ability to assess the mutagenicity of compounds is important in a wide-variety of areas ranging from drug discovery to industrial chemicals to environmental assessment. Animal model systems play an important role in mutagenicity assessment. While zebrafish and mice have enjoyed more attention, the transgenic Japanese medaka is a valuable alternative for environmental hazard assessment, toxicology and biomedical research.

Technology Summary

A researcher at the University of Georgia developed transgenic fish designed to extend and improve methods used to assess the potential genetic health risks posed by numerous agents (e.g. new chemical entities, mutagens in the environment, etc.). The fish were developed for in vivo quantitation of spontaneous and induced mutations using a recoverable mutation target gene and assay system.