Technologies

time icon May 18, 2016

Prevention and Treatment of Bacterial Infections by Promoting Host Innate Defense

Technology description

Background

Staphylococcus aureusis a gram-positive bacterium that is commonly known as the source of staph infections. The infection can cause a range of illnesses, varying from skin infections to life threatening conditions such as pneumonia and sepsis. Studies have shown that about one in three people (about 33%) is a carrier of the bacterium. Methicillin-resistantStaphylococcusaureus(MRSA) is a type of staph bacterium that is resistant to beta-lactam antibiotics such as methicillin, penicillin, oxacillin and amoxicillin. MRSA poses a serious health problem, especially in hospitals, nursing homes, and other facilities, but also in numerous public settings. There is an urgent need for new, effective prevention and treatment options for bacterial infections, and especially for MRSA infections.

Technology Description

Researchers at the University of New Mexico have developed a new treatment for bacterial infections by targeting the G protein-coupled Estrogen Receptor (GPER). Targeting the host immune response through GPER may provide protection against and treatment for infections caused by many human pathogens.

Publications

Innate Sex Bias of Staphylococcus aureus Skin Infection Is Driven by α-Hemolysin

About STC.UNM

As the technology-transfer and economic-development organization for the University of New Mexico, STC.UNM protects and commercializes technologies developed at the University of New Mexico (UNM) by filing patents and copyrights and transferring the technologies to the marketplace. We connect the business communication (companies, entrepreneurs and investors) to these UNM technologies for licensing opportunities and the creation of startup companies.

Application area

  • A sex-specific prophylactic and therapeutic target to enhance the host immune response to bacterial infection
  • Proof of principle has been demonstratedin vivoin a mouse model of methicillin-resistantStaphylococcus aureus(MRSA) skin infection
  • Treatment ofStaphylococcusaureusinfections, especially MRSA infections, in both male and female patients

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More information

Categories
  • Infectious Department
  • Diagnosis and treatment
Keywords:

background staphylococcus aureusis

life threatening conditions

numerous public settings

technology description researchers

protein-coupled estrogen receptor

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