SK-ES-1: Human Ewing Sarcoma Cell Line

Nov. 24, 2014

SK-ES-1: Human Ewing Sarcoma Cell Line

Technology description

SK-ES-1 is a human Ewing sarcoma (anaplastic osteosarcoma) cell line that displays epithelial morphology and grows in adherent tissue culture. These cells are a useful preclinical model to study Ewing sarcoma and have been used in the assessment of experimental therapeutic agents. SK-ES-1 cells form xenograft small-cell malignant tumors consistent with Ewing sarcoma when injected into immunocompromised mice. These cells have been reported to express mutant p53 (C176F) protein.

Source

This cell line was established in 1971 from a bone biopsy in an 18-year-old Caucasian male with Ewing's sarcoma.

Key References

Bloom ET (1972) Further definition by cytotoxicity tests of cell surface antigens of human sarcomas in culture.Cancer Research32: 960-967 (PubMed ID: 4502173 )
Komuro H et al. (1993) Mutations of the p53 gene are involved in Ewing's sarcomas but not in neuroblastomas.Cancer Research53: 5284-5288 (PubMed ID: 8221663 )
McCarty G, Awad O, and Loeb DM. (2011) WT1 protein directly regulates expression of vascular endothelial growth factor and is a mediator of tumor response to hypoxia.Journal of Biological Chemistry286: 43634-43643 (PubMed ID: 22030397 )
Sémiond D et al. (2013) Can taxanes provide benefit in patients with CNS tumors and in pediatric patients with tumors? An update on the preclinical development of cabazitaxel.Cancer Chemotherapy and Pharmacology72: 515-528 (PubMed ID: 23820961 )

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More information

Institution

Memorial Sloan-Kettering Cancer Center

Keywords:

displays epithelial morphology

experimental therapeutic agents

18-year-old caucasian male

key references bloom

taxanes provide benefit

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