Emory University researchers have developed a novel series of quinolines in which the dimethoxy phenyl substituent of CIQ is replaced with various heterocycles. Analogs based around the structure have been synthesized resulting in compounds with improved potency, efficacy, and drug-like properties compared to CIQ, while also maintaining subunit-selectivity for GluN2C and GluN2D. These compounds may be effective in treating a wide range of neurological disorders involving memory, learning and synaptic plasticity such as Alzheimer’s disease, Parkinson’s disease, depression, stroke, schizophrenia, and psychosis.
Subunit-selective GluN2C and GluN2D positive allosteric modulators of N-methyl-D-aspartic acid receptors (NMDAR) for treatment of neurological disorders.
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emory university researchers