Technologies

Vitamin D analogues with less calcemic effect and higher potency then Vitamin D can be used for suppressing renin biosynthesis. Treatment of patients with cardiovascular disease by administration of a therapeutically effective amount of a Vitamin D analog or Vitamin D receptor activator is expected to be advantageous for effective reduction of renin expression, decreased inflammation and improved cardiac function. Since ACE inhibitors, angiotensin II inhibitors, and aldosterone receptor blockers have different efficacies and affect the body through different pathways than Vitamin D does, compositions may include one of these agents in therapeutically effective amounts which are well known to inhibit activation of the renin-angiotensin system and readily available.