March 28, 2018
Bisposphonate compounds are used in the treatment of bone disorders such as osteoporosis and Paget’s disease and have been used to treat cancer. Radioactive imaging probes are used in conjunction with bisphosphonate drugs to monitor the effectiveness of the treatment. These radioactive imaging probes have low sensitivity and put the patient at risk for long-term toxic effects. There is a need for a more sensitive and less toxic bisphosphonate imaging probe.
USC researchers have developed numerous bisphosphonate imaging probes. These fluorescent probes show greatly increased sensitivity and lower potential long-term toxicity than the currently used radioactive imaging probes.
High sensitivity Low toxicity
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radioactive imaging probes
long-term toxic effects
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