Micropatterning of prothrombotic surfaces for measuring platelet function, coagulation, and anticoagulation

March 28, 2012

Micropatterning of prothrombotic surfaces for measuring platelet function, coagulation, and anticoagulation

Technology description

There is an unmet need in clinical hematology for global assays of hemostatic potential. We define global assays are those that incorporate all the major elements of clot formation including platelets, coagulation, blood flow, and endothelial function. This invention describes methods for patterning prothrombotic molecules on surfaces with micrometer precision The novelty of the invention is the description of methods to co-pattern molecules that induce platelet adhesion and aggregation, coagulation, and anticoagulation.

Application area

Potential Areas of Application ΓÇóCoagulation and platelet function testing ΓÇóEvaluation of antiplatelet and anticoagulation drugs

Advantages

Main Advantages of this Invention ΓÇóAbility to measure in both static and flow based assays ΓÇóIncorporates coagulation, anticoagulation and platelet function into one assay ΓÇóMore accurate than current methods

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