An Efficient MR Method for the Mapping and Measuring of Venous Oxygenation Using VSEAN

Feb. 1, 2012

An Efficient MR Method for the Mapping and Measuring of Venous Oxygenation Using VSEAN

Technology description

Summary

Oxygen consumption of the brain, measured by oxygen extraction fraction (OEF) provides important quantitative information on brain health and function. OEF is the fraction of the oxygen in arterial blood that is removed when the blood flows through a capillary bed. It is determined by subtracting SvO2 (venous oxygen saturation) from SaO2 (arterial oxygen saturation). SaO2 can readily be measured using a pulse oximeter. High OEF with reduced cerebral blood flow (CBF) depicts the at-risk tissue in acute stroke. OEF together with CBF can be used to obtain cerebral metabolic rate of oxygen (CMRO2), which provides an additional important quantitative assessment of brain metabolism and function.
Despite the importance of OEF and CMRO2 for clinical uses and basic neuroscience studies, a robust SvO2 mapping and measuring technique amenable to functional and clinical MRI has not been established.

Description

UC San Diego researchers have developed a robust MRI method for mapping/measuring venous oxygenation non-invasively.

Advantages

The method uses velocity selective excitation with arterial nulling (VSEAN) to increase signal-to-noise ratio (SNR) and reduce imaging time by effectively separating the venous blood signal from the arterial blood signal and static tissue signal.
The innovations include:

Velocity-selective excitation (VSE) pulses to image moving magnetization only.
Combination of VSE pulses with arterial nulling (AN) to acquire venous blood signal exclusively.
Combination of VSEAN and T2 prepared or multi-echo T2 measurement to map the venous T2 and oxygenation.

由于技术保密工作限制，技术信息无法完全展现，请通过邮箱或短信联系我们，获取更多技术资料。

More information

Institution

University of California, San Diego

Keywords:

important quantitative information

basic neuroscience studies

measuring technique amenable

robust svo2 mapping

robust mri method

下载 PDF 文档

Technologies