Sema4D suppresses neuronal hyperexcitability. Modulating GABAergic synapses via the Sema4D-PlexinB1 interaction to restore the balance of excitation and inhibition in brain.The researchers are interested in finding industry partners to pursue issues around drug production and delivery. For example, Sema4D is a large polypeptide that is unlikely to cross the blood brain barrier, thus making it a poor drug candidate.Nonetheless, these experiments are important proof of principle examining the in vivo effects and anti-seizure potential of driving inhibitory synapse formation in rodent models, using Sema4D administration as a tool.
R&D Required:
The researchers are interested in finding industry partners to pursue issues around drug production and delivery. For example, Sema4D is a large polypeptide that is unlikely to cross the blood brain barrier, thus making it a poor drug candidate. Nonetheless, these experiments are important proof of principle examining thein vivoeffects and anti-seizure potential of driving inhibitory synapse formation in rodent models, using Sema4D administration as a tool.
由于技术保密工作限制,技术信息无法完全展现,请通过邮箱或短信联系我们,获取更多技术资料。
finding industry partners
functional gabaergic synapses
modulating gabaergic synapses
devastating neurological disorders
autism spectrum disorders