Technologies

UCSD researchers have found thata tissue specific gene deletion of CAP in the macrophage results in a similar protection from insulin resistance without limiting the exercise capacity in the host. By transplanting CAP deleted bone marrow to normal mice, macrophage-specific deletion of CAP was achieved. CAP deletion in the macrophage appeared to protect target tissues such as the muscle and liver from impaired insulin sensitivity without incapacitating the mouse. Thus, targeting CAP in the macrophage may be effective in treating patients in impaired glucose tolerance and/or type 2 diabetes.