Technologies

Abstract

Investigators at Northwestern have designed biodegradable nerve guidance conduits or bridges possessing multiple features for promoting nerve regeneration including the ability to deliver DNA, protein, and/or small molecules. These conduits serve as a mechanical support to promote and direct tissue regeneration by creating a path for neurite outgrowth and exclude invading tissue from the injured space. The conduits may be structured as either a single, large channel or multiple small channels. Moreover, the fabrication method allows for a time-controlled release of therapeutic agents that aid tissue regeneration. The fabrication process avoids the use of organic solvents, aqueous/organic emulsions and elevated temperatures required by alternative methods, allowing a wide range of therapeutics to be incorporated: DNA, proteins, as well as small molecules. These combinations can be tailored to encourage tissue formation. An additional advantage is the potential to spatially regulate the incorporation of therapeutic agents and regulate the concentration of different growth factors throughout the conduit.