Jan. 30, 2017
Fungal disease of organ systems such as the lungs, skin, and musculoskeletal tissues can be devastating in immunocompromised populations, such as patients suffering from cancer or recovering from organ transplantation. Furthermore, complications associated with medical implant and medical device-related infections have created a significant clinical need for novel materials capable of both stimulating tissue regeneration and mitigating fungal infections.
Rice researchers have designed a novel class of diol-based, unsaturated, aliphatic polyesters that biodegrade into monomers capable of mitigating infection. This new class of polymers, the poly(diol fumarates) (PDFs) and poly(diol fumarate-co-succinates) (PDFSs), can be cross-linked to form networks of scaffolds with antimicrobial degradation products. Both the diol carbon chain length as well as degree of available double bonds for functionalization are tunable, and provide for a highly controllable class of antimicrobial polymers.
The utility of this technology includes uses as cellular scaffolds and drug delivery vehicles for biomedical applications. This technology may find use in a number of devices ranging from regenerative medicine to drug delivery. Tunability of these polymers enhance the range of biomedical applications compared to existing biomaterials.
由于技术保密工作限制，技术信息无法完全展现，请通过邮箱或短信联系我们，获取更多技术资料。
challenge fungal disease
stimulating tissue regeneration
solution rice researchers
medical device-related infections
mitigating fungal infections
B5, No.1600, North Guoquan Rd, Yangpu, Shanghai
info@yintrust.com
021-65679356
Premium