System And Method For Performing In Vivo Imaging And Oxymetry By Pulsed Radiofrequency Electron Paramagnetic Resonance
Technology description
Summary
This invention provides a non-invasive system for in vivo imaging by fast-response pulsed radiofrequency (RF) electron paramagnetic resonance (EPR) spectroscopy. The imaging system can be used for measurement and 3-dimensional imaging of oxygen and free radicals in living systems, in conjunction with appropriate free radical probes.The short relaxation time of the probes and the fast response associated with pulsed EPR techniques permit virtual real-time imaging. The system uses a magnetic field of only 10 mT-orders or magnitude smaller than the field used in conventional MRI techniques. The sensitivity, image resolution, and imaging speed of the pulsed RF EPR system are far superior to continuous wave RF EPR systems.
Application area
The system can be used to perform rapid 3-dimensional mapping of tissues and vasculature, for example cardiac and cerebral angiography, and also to distinguish normal and diseased tissues.