Technologies

Solution

The device can be used to detect and stage tumors, to image specific cellular and molecular processes (e.g. gene expression, or more complex molecular interactions such as protein-protein interactions), to monitor multiple molecular events simultaneously, to track single- or dual-labeled cells using reporter genes or dual-modal labels visible to both optical and MR imaging, to optimize drug and gene therapy, to image drug effects at a molecular and cellular level, to assess disease progression at a molecular pathological level, especially to create the possibility of achieving all of the above goals of imaging in a single, rapid, reproducible, and quantitative manner.

Figure 1: Optical detector with micro lenses; (22) Micro-lenses

Figure 2: Schematically perspective view of a section of a dual-modality imaging system with micro-lens arrays and photo detectors at the focal planes of the micro lens arrays; 20) Detector block, (21) Micro-lens array, (23) Filter, (24) Optical collimator. (25) Photo detector, (26) Electronic parts and signal transmission elements, (27) Imaged object, (28) Light sources, (29) Light ray, (30) Gaps

References

1. “Iterative reconstruction of projection images from a microlens-based optical detector.” By Cao L, Peter J. published in Opt Express. 2011 Jun 20;19(13):11932-43. doi: 10.1364/OE.19.011932. PMID: 21716427. See: https://www.ncbi.nlm.nih.gov/pubmed?term=21716427
2. “Image formation with a microlens-based optical detector: a three-dimensional mapping approach.” By Unholtz D, Semmler W, Dössel O, Peter J. published in Appl Opt. 2009 Apr 1;48(10):D273-9. PMID: 19340119. See: https://www.ncbi.nlm.nih.gov/pubmed?term=19340119
3. “A novel optical tomographic instrument for multimodal imaging application in mice” in J. Nucl. Med. 2011; 52 (Supplement 1):1958; by Joerg Peter and Liji Cao; Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Germany; Abstract No. 1958.