Antibodies Against Synaptic Proteins

Jan. 29, 2004

Antibodies Against Synaptic Proteins

Technology description

Monoclonal antibodies reactive against a wide range of synaptic proteins.

Description

Most pharmacological approaches to neuropsychiatric disorders involve attempts to block postsynaptic receptors or inhibit presynaptic neurotransmitter uptake. Recent work indicates that families of proteins are involved in the presynaptic mechanisms of neurotransmitter secretion. Antibodies reactive with these proteins can be used to demonstrate alterations in presynaptic mechanisms in a wide range of neuropsychiatric disorders. Certain synaptic proteins are susceptible to the action of neurotoxins. Using anti- synaptic antibodies as proves into mechanisms of illness, and as reagents to permit characterization of presynaptic proteins, may lead to the development of entirely new therapeutic strategies for such illnesses as Alzheimer disease, temporal lobe epilepsy and schizophrenia.

由于技术保密工作限制，技术信息无法完全展现，请通过邮箱或短信联系我们，获取更多技术资料。