Technologies

Executive Summary

NF-kB is a transcription factor that regulates a large number of genes and biochemical pathways, including those involved in immune, inflammatory, and anti-apoptotic responses. Many areas of drug discovery are focused on developing reagents that regulate NF-kB. Imidazolines are potent inhibitors of NF-kB, and are currently being used to treat a wide variety of medical conditions, including asthma, arthritis, fungal infections and hypertension. Imidazolines exhibit other properties which make them potentially useful in enhancing the activity of chemotherapy agents.

Description of Technology

This technology consists of a new class of multi-substituted 4-acid or 4-alkyl ester imidazoline compounds that exhibit anti-microbial, anti-sepsis and anti-inflammatory activity. In addition, they potentially inhibit resistance to chemotherapy reagents. This invention describes the use and an improved method for synthesis and production of these unique imidazoline compounds.