Technologies

time icon Jan. 5, 2015

Inhibition of an Inflammation Associated Kinase as a Sole or Combination Treatment for Gastrointestinal Cancers

Technology description

A method of treating gastrointestinal cancer using a novel pharmaceutical composition that inhibits a pro-inflammation protein kinase.

This method is likely to reduce the possibility that a cancer will metastasize in a patient with cancer or recur in a patient whose cancer is in remission. This unique composition is involved in multiple cellular processes such as inflammatory responses, gene expression regulation, and cell proliferation.

Background

Gastrointestinal (digestive system) cancers include cancers of the stomach and colon. According to the National Cancer Institute, there are an estimated 22,200 new cases and 11,000 deaths from stomach cancer currently in the U.S. Stomach cancer forms in tissues lining the stomach and is also called gastric cancer. Colorectal cancer forms in the tissues of the colon (the large intestine) and there are approximately 150,000 new cases of colorectal cancer and over 50,000 deaths from this disease in the U.S. each year.

There are different types of treatment options for patients with gastrointestinal cancers. The standard treatments can include surgery, chemotherapy, radiation therapy, chemoradiation, and/or targeted therapies. With gastrointestinal cancers affecting so many, there exists an urgent need for more effective therapies and treatments.

Technology Description

Researchers at the University of New Mexico have developed a method of treating gastrointestinal cancer using a novel pharmaceutical composition that inhibits a pro-inflammation protein kinase. This method is likely to reduce the possibility that a cancer will metastasize in a patient with cancer or recur in a patient whose cancer is in remission. This unique composition is involved in multiple cellular processes such as inflammatory responses, gene expression regulation, and cell proliferation.

About STC.UNM

As the technology-transfer and economic-development organization for the University of New Mexico, STC.UNM protects and commercializes technologies developed at the University of New Mexico (UNM) by filing patents and copyrights and transferring the technologies to the marketplace. We connect the business communication (companies, entrepreneurs and investors) to these UNM technologies for licensing opportunities and the creation of startup companies. Visit www.stc.unm.edu.

Application area

  • Novel and clinically-significant therapy capable of supplementing and complementing known anti-cancer regimens
  • Excellent target for the inhibition and/or treatment of cancer
  • Leads to a decrease in cancer cell proliferation
  • Significant results of mice not developing gastric or colon tumors in established models of both tumor types have been shown
  • May also be used as a treatment for inflammatory bowel disease
  • Applications include: treatment of gastric and/or colon cancers, including drug resistant cancers and recurrent cancers, and cancer research.

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More information

Categories
  • Information technology
  • Psychiatry
  • Gastrointestinal surgery
Keywords:

pro-inflammation protein kinase

multiple cellular processes

gene expression regulation

technology description researchers

and/or targeted therapies

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