Treatment for Diabetic Cardiomyopathy

Feb. 1, 2012

Treatment for Diabetic Cardiomyopathy

Technology description

Description

Heart disease is the lead cause of mortality among diabetic patients in the U.S. UC San Diego researchers have developed a method to treat diabetic cardiomyopathy by gene therapy using an enzyme specific for the removal of a single sugar molecule from proteins such as transcription factors. The researchers demonstrated that elevated extra-cellular glucose levels result in impaired calcium cycling in myocytes, leading to impaired cardiac contractility and poor myocardial performance, by a mechanism involving O-linked glycosylation of nuclear proteins. They found that these effects can be reversed by gene therapy with an enzyme, O-GlcNAcase, which can remove specific O-linked hexosamines from proteins. Delivery of viral vectors encoding O-GlcNAcase to myocytes from diabetic rats markedly improved calcium flux and contractile function.

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