Technologies

time icon Feb. 17, 2012

Use of intratracheally administered hyaluronic acid to ameliorate emphysema

Technology description

A major cause of respiratory diseases, like chronic bronchitis and emphysema, is the losselasticity in the lung. This characteristic of lung tissue is mediated in part by proteins called elastins; thelack of them causes alveoliar rupture. Similarly, damage to blood vessel during aging, the uterus duringpregnancy, aortic aneurysms and arthritis are linked to reduction in elasticity. Hyaluronic acid (also calledhyaluronan or hyaluronate) is a large carbohydrate molecule distributed throughout neural, epithelial andconnective tissue. Hyaluronic acid has been FDA approved for various therapies, from osteoarthritis towrinkle removal, and high yield synthesis methods are commonplace.The invention provides a unique application of this carbohydrate as a therapy for respiratorydisease, or any disease involving elastic fiber injury in tissues. Research by the inventor has shown thatmaintaining the elasticity of lungs by protecting the elastin proteins from degradation also maintains lungfunction. Indeed, an anti-trypsin drug (an extracellular enzyme which cleaves elastins) is already inclinical trials. Mice studies indicate that protection occurs because hyaluronic acid directly binds elastins,thus precludes degradation. Intratracheal administration of hyaluronic acid may have significantadvantages over symptomatic treatments, bronchodilators and oxygen supplementation, since it can haltfurther lung damage. Similarly, hyaluronic acid therapy may be preferred to trypsin inhibitors because itmay block other endogenous elastases.Potential Commercial

Application area

- Respiratory diseases: emphysema, chronic bronchitis, asthma, pulmonary edema, acuterespiratory distress syndrome, bronchopulmonary dysplasia, pulmonary fibrosis, and pulmonaryatelectasis.- Injured tissue: uterus after pregnancy, circulatory system aneurysms and arthritic diseases

Advantages

- Provides a method to protect elasticity in lung, arterial and other organ tissues from mostdegrading enzymes.- Prevents progression of injuries in elastic tissues, thus preferable over current symptomatictreatments.- Can be applied as a prophylactic therapy in high risk individuals.- Methods exist for high purity hyaluronic acid synthesis.- FDA approved as safe for human therapy.

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More information

Institution
Categories
  • Respiratory medicine
  • Information technology
Keywords:

osteoarthritis towrinkle removal

epithelial andconnective tissue

proteins called elastins

haltfurther lung damage

hyaluronic acid therapy

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