June 23, 2017
Traumatic events, surgical procedures, and missing teeth often leave a condition in which there is poor quality and quantity of bone, requiring patients to receive a bone graft. An estimated 2.2 million bone grafting procedures are performed annually worldwide at a cost of $2.5 billion. The capacity to quickly regenerate or augment bone loss is crucial to restoring function, and current autologous and allogenic bone grafts fall short, requiring second surgical procedures and introducing the potential for disease transmission respectively. Additionally, it is contemplated that providing mechanical support in conjunction with delivery therapeutic compounds at the surgical site can aid in improving the recovery process. However, the differing rates of absorption and metabolism can make effective delivery complicated.
Researchers at the University of Kentucky have invented subject matter that provides for a bilayered composite to provide both mechanical support and localized drug delivery for the improvement of bone regeneration or augmentation. The present invention relates generally to methods for the production of a strong biocompatible material that can effectively promote osteogenesis while simultaneously acting as an effective barrier and/or support, thus preventing disruptive tissue infiltration. Additionally, the bilayered compounds can degrade or erode at different rates in situ, allowing for administration of therapeutic compounds. Other advantages may include convenience, economy of cost, and technical time.
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performed annually worldwide
technology solution researchers
invented subject matter
localized drug delivery
strong biocompatible material
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