June 25, 2018
A novel, non-radioactive, alternative MRI imaging agent that may replace 18 FDG PET imaging of tumors and other tissues where glucose consumption is high.
The alternative agent, which is labeled with oxygen-17, can be synthesized through straightforward chemistry and is expected to accumulate in select tissues in the same manner as the current 18 FDG agent. Accumulation of the alternative agent will allow for indirect image enhancement of H-MRI and can be used for direct O-MRI, with hyperpolarization affording increased sensitivity both for indirect and direct imaging. Studies conducted on mice using other compounds labeled with oxygen-17 have demonstrated the feasibility of replacing PET with MRI using this novel, non-radioactive, alternative agent. The alternative agent is easier to prepare than the currently used 18 FDG, allows for a wider use of commonly used MRI imaging instruments, and has therapeutic as well as diagnostic potential (theranostic potential).
Positron emission tomography (PET) is a nuclear medicine, functional imaging technique that is used to observe metabolic processes in the body. PET scans can be used to detect cancerous tissues and cells in the body that may not always be found through computed tomography (CT) or magnetic resonance imaging (MRI). The PET system detects pairs of gamma rays emitted indirectly by a positron-emitting radionuclide (tracer), which is introduced into the body on a biologically active molecule. 18 F-fluorodeoxyglucose ( 18 FDG) is currently the radiopharmaceutical most widely used in PET scans to aide in the detection of tumor cells and other cells with high glucose consumption. Exposure of adults to radiation from PET imaging with 18 FDG is not considered to be dangerous. However, it is not recommended for pregnant women and children. Post resection or treatment surveillance is often needed for young children, requiring more CT and PET exposure to radiation with yearly or biannual imaging screening. PET scanners also carry high operating costs compared to CT and MRI alternatives. There exists is a need for a non-radioactive and affordable, alternative imaging agent with the same effectiveness and detection capabilities as the currently used radiopharmaceutical 18 FDG.
Researchers at the University of New Mexico have proposed the development of a novel, non-radioactive, alternative MRI imaging agent that may replace 18 FDG PET imaging of tumors and other tissues where glucose consumption is high. The alternative agent, which is labeled with oxygen-17, can be synthesized through straightforward chemistry and is expected to accumulate in select tissues in the same manner as the current 18 FDG agent. Accumulation of the alternative agent will allow for indirect image enhancement of H-MRI and can be used for direct O-MRI, with hyperpolarization affording increased sensitivity both for indirect and direct imaging. Studies conducted on mice using other compounds labeled with oxygen-17 have demonstrated the feasibility of replacing PET with MRI using this novel, non-radioactive, alternative agent. The alternative agent is easier to prepare than the currently used 18 FDG, allows for a wider use of commonly used MRI imaging instruments, and has therapeutic as well as diagnostic potential (theranostic potential).
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