Technologies

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Producing Protein Microspherse/Nanospheres with Narrow Size Distribution

Overview

The invention provides a method for producing zein (corn protein) microspheres and nanospheres. The microspheres and nanospheres are restricted to narrow size ranges and are useful in producing drug delivery and biomedical applications.

Technology

This invention describes the composition and method to produce the zein particles at either micron or nanometer sizes. Particle size, shape, and distribution is important because it can significantly affect drug release behavior, biodistribution, body clearance, and toxicity. Past methods produce a wide size distribution of spheres, which would not allow for uniform drug delivery kinetics. A method to develop narrow particle size distribution is needed for product uniformity and predictable drug release. This method involves dissolving the zein into a mixture of water and an organic solvent. This technology can be used for protein delivery, DNA transfection, vaccine delivery, and tissue engineering. This method’s feature allows the zein particles to be converted to a suitable shape and size and blended with other biopolymers.

Research Interests

• Nanoparticles for drug delivery
• Cellular trafficking of nanoparticles