Compounds which can induce melanin expression to aid in certain clinical indications or for cosmetic purposes.
Problem Solved by This Technology
Melanin is important for disease prevention, because it absorbs ultraviolet light in the UVB and UVA spectrum. This protects keratinocytes from the mutagenic effects of sunlight. In addition, melanin has a social function, as it determines skin and hair color. Agents that increase melanin synthesis are of interest, because of their potential use as “natural sunscreens” that stimulate the skin’s resident melanocytes to produce and transfer more melanin to epidermal keratinocytes, thus potentially decreasing the incidence of skin cancer. There is a significant need to identify new compounds with improved ability to induce melanin production and transfer.
Publication
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publication mcnaughton br
induce melanin expression
increase melanin synthesis
induce melanin production
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