March 6, 2015
Monoclonal antibody for detection of human rheumatoid cells
#researchtool #antibody #reagent
A Northwestern University researcher discovered a differentially regulated antigen on the surface of endothelial cells that is associated with allergic contact dermatitis. The monoclonal mouse antibody developed against this antigen reacts with vascular endothelial cells in lymphoid tissues and endothelial cells in diseased tissue such as rheumatoid and osteoarthritic synovium, psoriatic skin, adrenal tumors and cutaneous Kaposi's sarcomas. It does not react with several myeloid or lymphoid cell lines, peripheral blood cells and platelets. Additionally, this antibody does not detect endothelium of medium-sized vessels and that of normal tissues such as liver and spleen. Therefore, this antibody can a useful reagent to distinguish between endothelial cells from normal and diseased tissue samples.
Publications
Koch AE, Burrows JC, Domer PH, Ashmun RA, Look AT, Leibovich SJ (1992). Monoclonal antibodies defining shared human macrophage-endothelial antigens,Pathobiology.60: 59-67.
由于技术保密工作限制，技术信息无法完全展现，请通过邮箱或短信联系我们，获取更多技术资料。
cutaneous kaposi's sarcomas
lymphoid cell lines
abberant vascular endothelium
peripheral blood cells
differentially regulated antigen
B5, No.1600, North Guoquan Rd, Yangpu, Shanghai
info@yintrust.com
021-65679356
Premium