Marine Natural Product Yields Cancer Therapeutic (NCE)

March 23, 2017

Marine Natural Product Yields Cancer Therapeutic (NCE)

Technology description

UC inventors have used human cancer bio-assays to identify, isolate and characterize novel compositions from marine cyanobacteria. Subsequent work with parent compounds and potent analogs has yielded compositions of matter, methods for synthesis and methods of using Apratoxins F & G to treat cancer.

SIO scientists have mined their rare collection of marine organisms to identify, characterize and analog a proprietary, small molecule with anti-cancer properties. SAR studies have identified regions of the molecule that have yielded analogs of greatest interest. Compositions of matter and methods of use are claimed for the treatment of cancer and hyperproliferative disorders.

Intellectual Property Info

Worldwide rights available for pending patent application WO2011/112893 .

Related Materials

Grindberg RV et al., Single cell genome amplification accelerates identification of the apratoxin biosynthetic pathway from a complex microbial assemblage. PLoS One. 2011 Apr 12;6(4):e18565. (link to: http://www.ncbi.nlm.nih.gov/pubmed/21533272)
Tidgewell K et al., Evolved diversification of a modular natural product pathway: apratoxins F and G, two cytotoxic cyclic depsipeptides from a Palmyra collection of Lyngbya bouillonii. Chembiochem. 2010 Jul 5;11(10):1458-66. (Link to: http://www.ncbi.nlm.nih.gov/pubmed?term=Evolved diversification of a modular natural product pathway: apratoxins F and G, two cytotoxic cyclic depsipeptides from a Palmyra collection of Lyngbya bouilloni)
Gutiérrez M et al., Apratoxin D, a potent cytotoxic cyclodepsipeptide from papua new guinea collections of the marine cyanobacteria Lyngbya majuscula and Lyngbya sordida. J Nat Prod. 2008 Jun;71(6):1099-103. (link to: http://www.ncbi.nlm.nih.gov/pubmed/21533272)
Luesch, H et al. , A functional genomics approach to the mode of action of apratoxin A. Nat Chem Biol, 2006, 2(3), 158-167 (link to: http://www.ncbi.nlm.nih.gov/pubmed?term=A Functional Genomics Approach to the Mode of Action of the Antiproliferative Natural Product Apratoxin A )

Additional Technologies by these Inventors

Related Cases

2010-216-0

Application area

Whilein vivostudies have not confirmed which drugs will be most useful for which cancers, studies suggest the first targets may be solid tumors, particularly colon cancer. In general, any disease or condition characterized by hyperproliferative cell growth may benefit from this therapeutic approach.

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